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Video Presentation -Overweight/obesity increases ventilatory capacity and reduces FeNO in asthmatic children

By Anonymous

Title: Overweight/obesity increases ventilatory capacity and reduces FeNO in asthmatic children
By Dr. Maria Michelle Papamichael
Statement of Problem: Universally, bronchial asthma is the most common chronic respiratory disorder in children characterized by airway inflammation, bronchial hyperresponsiveness and recurrent episodes of reversible airway obstruction. Excess weight represents a major global health challenge because of adverse health outcomes including asthma. The concurrent rise in asthma and pediatric obesity postulate a possible link between the two conditions. Excess weight may impact asthma via multiple mechanisms including pulmonary mechanics, lifestyle, dietary, immunological, hormonal and common genetic factors. High bodyweight was found to be associated with reduced pulmonary function and Fractional exhaled Nitric Oxide (FeNO) in adult subjects. Yet the current literature focusing on the effect of obesity and overweight on lung function and FeNO in asthmatic children remains controversial. The objective of this study was to investigate the effect of excess weight on pulmonary function and exhaled nitric oxide in a sample of 72 Greek asthmatic children (5-12 years old) participating in a Mediterranean diet and childhood asthma intervention study. 
Methodology: Pulmonary function was assessed using spirometric measures (FEV1, FVC, FEV1/FVC, PEF, FEF 25-75%) and eosinophilic bronchial inflammation by FeNO. Body Mass Index (weight/height2) was used to measure excess bodyweight and categorized using age- and sex-specific BMI cut-off values for ages 2-18 years as proposed by the International Obesity Task Force (normal weight (≧17 and <25 kg/m2), overweight (≧25 and <30 kg/m2), and obese (≧30 kg/m2). Findings: Data analysis showed a positive linear relationship between BMI and FVC (p=0.01) and FEV1 (p=0.03). FeNO was lower in the overweight/obese group as compared to normal weight (p=0.03). 
Conclusion & Significance: High BMI in asthmatic children was associated with increased lung volume (FVC) and airflow (FEV1) along with reduced FeNO. Future research is needed to establish whether disproportionate lung growth and non-eosinophilic bronchial inflammation might be the underlying mechanisms for this paradox.




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Comments

  1. Lisa Kenneth2 May 2020 at 08:37

    I'm 57 years old and female. I was diagnosed a couple of years ago with COPD and I was beyond scared! My lung function test indicated 49% capacity. After having had flu a year ago, the shortness of breath, coughing and chest pains continued even after being treated with antibiotics. I've been smoking two packs a day for 36 years. Being born without a sternum caused my ribs to be curled in just one inch away from my spine, resulting to underdeveloped lungs. At age 34 I had surgery and it was fixed. Unfortunately my smoking just caused more damage to my already under developed lungs. The problem was having is that I enjoy smoking and don't want to give up! Have tried twice before and nearly went crazy and don't want to go through that again. I saw the fear in my husband and children's eyes when I told them about my condition then they start to find solution on their own to help my condition.I am an 57 now who was diagnose COPD emphysema which I know was from my years of smoking. I started smoking in school when smoking was socially acceptable. I remember when smoking was permitted in hospitals. It was not known then how dangerous cigarettes were for us, and it seemed everybody smoked but i was able to get rid of my COPD lung condition through the help of  Dr Akhigbe   total cure herbal medicine. my husband saw his testimony on the internet he used his powerful medicine to cured different diseases. we contacted his email   [drrealakhigbe@gmail.com}   He has the right herbal formula to help you get rid and repair any lung conditions and others diseases, will cure you totally and permanently with his natural organic herbs,We received the medicine through courier delivery service. I wish anybody who starts smoking at a young age would realize what will eventually happen to their bodies if they continue that vile habit throughout their life.
    Dr Akhighe also cured diseases like, HERPES, DIABETES, HIV/AIDS, COPD, CANCER,ASTHMA,STROKE,LUPUS,JOINT PAIN,CHRONIC DISEASES,PARKINSON DISEASES,TUBERCULOSIS,HIGH BLOOD PRESSURE,BREAST INFECTION,WOMEN SEXUAL PROBLEM, ERYSIPELAS,STAPHYLOCOCCUS,HEPATITIS A/B, QUICK EJACULATION,GONORRHEA,SYPHILIS,WAST/BACK PAIN,PELVIC INFLAMMATORY, DICK ENLARGEMENT,HEART DISEASES,TERMINAL ILLNESS,SHIFT IN FOCUS,ATAXIA,COMMON COLD,CROHN'S DISEASES,ALCOHOL SPECTRUM DISORDER,GRAVES DISEASE,HEARING LOSS, INTERSTITIA CYSTITIS,LEUKEMIA,MULTIPLE SCLEROSIS,OBESITY,RABIS,SCOLIOSIS,INFLUENZA, POLIO,JACOB,ETC. If you are out there looking for your cure please  contact  dr Akhigbe  by his email    drrealakhigbe@gmail.com     or contact his whatsapp number   +2349010754824
    God bless you Dr Akhigbe for your good hand work on my life.

    ReplyDelete
  2. Florence10 April 2021 at 04:42

    I started on COPD Herbal treatment from Ultimate Health Home, the treatment worked incredibly for my lungs condition. I used the herbal treatment for almost 4 months, it reversed my COPD. My severe shortness of breath, dry cough, chest tightness gradually disappeared. Reach Ultimate Health Home via their email at ultimatehealthhome@gmail.com . I can breath much better and It feels comfortable!

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